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KMID : 0379520160320040327
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한국독성학회지
2016 Volume.32 No. 4 p.327 ~ p.335
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Reproductive and Developmental Toxicity Screening Test of Ethyl Hydrogen Adipate in Rats
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Nam Chun-Ja
Hwang Jae-Sik
Han Kyoung-Goo
Jo Eun-Hye
Yoo Sun-Kyoung
Eom Ig-Chun
Kang Jong-Koo
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Abstract
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This study aimed to evaluate the potential toxicity and safety of ethyl hydrogen adipate (EHA) by determining its effect on the reproductive function and development of Sprague-Dawley (SD) rats at dose levels of 0 (control), 200, 400, and 800 mg/kg/day. One male and five females of the 800 mg/kg/day died. Body weight loss was observed in the males of the 800 mg/kg/day and in females of the 400 and 800 mg/kg/day. In addition, mating indices decreased and pre-implantation loss rates increased in parental animals of the 400 and 800 mg/kg/day. The gestation index decreased in the male and female rats of the 800 mg/kg/day. Moreover, the body weight of the pups from the 800 mg/kg/day group decreased on post-parturition day 4. These results indicated that the no-observed-adverse-effect level of EHA for parental males and females was 400 mg/kg/day and 200 mg/kg/day, respectively, and that for pups was 400 mg/kg/day.
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KEYWORD
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Ethyl hydrogen adipate, Reproductive and development toxicity, Screening test, Rat
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